Domperidone Maleate

220 Registered Brands From ৳1.00 / unit ⚕️ Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs

💊 Brands & Prices (220) 📋 Indications & Uses 💊 Dosage & Administration ⚠️ Contraindications ⚡ Side Effects & Adverse Reactions 🛡️ Warnings & Precautions 🔬 Pharmacology & Mechanism

💊 Brand Formulations & Prices

220 brands sorted by unit price

📖 Official Clinical Monograph

DGDA Approved Prescribing Guidelines

📋 Indications & Uses

Adegut is indicated in-
Dyspeptic symptom complex
, often associated with delayed gastric emptying, gastroesophageal reflux and esophagitis:
Epigastric sense of fullness, feeling of abdominal distension, upper abdominal pain
Eructation, flatulence, early satiety
Nausea and vomiting
Heartburn with or without regurgitations of gastric contents in the mouth
Non-ulcer dyspepsia
Acute nausea and vomiting
of the functional, organic, infectious, dietetic origin or induced by radiotherapy or drug therapy or induced in migraine.
Parkinson's disease
: In dopamine-agonist induced nausea and vomiting.
Radiological studies
: Speeding barium transit in follow-through radiological studies.

💊 Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.
The usual recommended oral dose of Domperidone is as follows:
Adults
: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
Children
: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.
In dyspeptic symptom:
Adults
: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
Children
: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.
In acute and sub-acute conditions (mainly in acute nausea and vomiting):
Adults
: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
Children
: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).
By rectum in suppositories:
Adults (including elderly)
: 30-60 mg every 4-8 hours.
Children
: The maximum daily dose rectally in children's is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
The maximum period of treatment is 12 weeks.

⚠️ Contraindications

Domperidone is contraindicated to patients having known hypersensitivity to this drug and in the case of neonates. Domperidone should not be used whenever gastrointestinal stimulation might be dangerous i.e., gastrointestinal hemorrhage, mechanical obstruction or perforation. Also contraindicated in patients with prolactin releasing pituitary tumor (prolactinoma).

⚡ Side Effects & Adverse Reactions

Side-effects are rare; exceptionally some transient intestinal cramps have been reported. Extrapyramidal phenomena are rare in young children and exceptional in adults: they reverse spontaneously and completely as soon as the treatment is stopped. As the pituitary gland is located outside the blood-brain barrier, domperidone may induce an increase in the plasma prolactin level. In rare case this hyperprolactinaemia may give rise to neuroendocrinological phenomena such as galactorrhoea and gynaecomastia. When the blood-brain barrier is immature (as in infants) or impaired, the possible occurrence of neurological side-effects cannot be totally excluded. Rare allergic reactions, such as rash and urticaria, have also been reported.

🛡️ Warnings & Precautions

Adegut should be used with absolute caution in the case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier. Since domperidone is highly metabolized in liver, it should be used with caution in patient with hepatic impairment.

🔬 Pharmacology & Mechanism

Domperidone is a dopamine antagonist that principally blocks the dopamine receptors located in the ChemoreceptorTrigger Zone (CTZ) and stomach. Its gastroprokinetic action is based on its blocking effect of dopamine receptors that have an influence on the motility of the gastrointestinal tract. Due to its weak penetration across the blood-brain barrier, Domperidone has almost no effect on the dopaminergic receptors in the brain, therefore, excluding psychotropic and neurologic side effects. Domperidone restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis and regulates contraction of the pylorus. Domperidone also increases esophageal peristalsis and lower esophageal sphincter pressure, and thus prevents regurgitation of gastric content.

Domperidone Maleate

💊 Brand Formulations & Prices

Bpdon

Motodon

Motodon

P-Don

Dedom

Remadon

Adegut

Adorex

Anet

Apedom

Atidon

Bedom

Beridom

Cpdom

D-Peridone

DP-Done

Degut

Domp

Dompa

Dompen

Domperid

Domperidon

Domperon

Domstal

Doperon

Dopon

Edone

Emedon

Gidora

I-POP

Loridon

Merin

Motilium

Motiper

Myodon

Nudom

Omid

Omidon D

Peri

Pradom

Sydon

Virdon

Vomino

Xepadon

Gidonic

Loval

Motigen

Motil

Prokinet

Sandom

Regut

Dominat

Domsil

Perion

Domerin

Domfix

Domigut

Dominaaf

Dompi

Emidom

Eridon

Makdom

Moticare

Nudon

Perigut

Peristal

Ridon

SB-Dom

Sagdon

Umodin

Normogut

Almigut

Apidone

Domidon

Dompa-S

Dopadon

Dopagut

Dopatic