Digoxin

Agoxin is indicated in:
Heart failure.
Atrial fibrillation with an uncontrolled ventricular rate.
Acute left ventricular failure.
Chronic left ventricular failure and conjestive heart failure, especially when caused by hypertensive valvular (especially mitral valvular) disease or ischaemic heart disease.

By oral administration:
Rapid digitalization
: 1-1.5 mg in divided doses over 24 hours
Less urgent digitalization
: 250-500 micrograms daily (higher dose may be divided)
Maintenance
: 62.5-500 micrograms daily (higher dose may be divided) according to renal function and in atrial fibrillation on heart rate response.
Usual range
: 125-250 micrograms daily (lower dose may be divided) according to renal function and in atrial fibrilation on heart rate response.
Usual range
: 125-250 micrograms daily (lower dose may be appropriate in the elderly).

Usually associated with excessive dosage include anorexia, nausea, vomiting, diarrhoea, abdominal pain, visual disturbance, headache, fatigue, drowsiness, confusion, delirium, hallucination, depression, arrhythmia, heart block, intestinal ischaemia, gynaecomastia on long term use, thrombocytopenia reported. Agoxin can be safely used in pregnancy

Digoxin is a cardiac glycoside used in the management of particularly atrial fibrillation and in heart failure.The principal actions of digoxin are an increase in the force of myocardial contraction (positive inotropic activity and a reduction in the conductivity of the heart particularly in conduction through the atrioventricular node. Digoxin also has a direct action on vascular smooth muscle and indirect effects mediated primarily by the autonomic nervous system and particularly by an increase in vagal activity.