Cilnidipine

Bidip is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Bidip has been increasingly used in patients with chronic kidney disease
Hypertension is the term used to
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Bidip is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Bidip has been increasingly used in patients with chronic kidney disease
Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel.

Dosage & Administration

Adults
: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily.
Pediatric use
: The safety of Cilnidipine in pediatric patients has not been established.
Elderly use
: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).

The most common side effects of Bidip are: Dizziness; flushing; headache; hypotension; peripheral oedema; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression.

Cilnidipine is a dihydropyridine calcium-channel blocker. Cilnidipine binds to the dihydropy-ridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca
2+
influx across the cell membranes of vascular smooth muscle cells via this channel, consequently vascular smooth muscle is relaxed, causing vasodilation. Cilnidipine inhibits Ca
2+
influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane. The inhibition of Ca
2+
influx via N-type voltage dependent calcium channel was observed over a similar range of drug concentrations to those inhibiting L-type voltage dependent Ca
2+
channels. Consequently, release of norepinephrine from sympathetic nerve terminals would be inhibited. Cilnidipine is considered to suppress the reflex increase in heart rate after blood pressure reduction.