Cephradine

288 Registered Brands From ৳6.25 / unit ⚕️ First generation cephalosporins

💊 Brands & Prices (288) 📋 Indications & Uses 💊 Dosage & Administration ⚠️ Contraindications ⚡ Side Effects & Adverse Reactions 🛡️ Warnings & Precautions 🔬 Pharmacology & Mechanism

💊 Brand Formulations & Prices

288 brands sorted by unit price

📖 Official Clinical Monograph

DGDA Approved Prescribing Guidelines

📋 Indications & Uses

Abac is indicated for the treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria. These include-
Undesirable Upper respiratory tract infections
: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis and otitis media, and also
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Abac is indicated for the treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria. These include-
Undesirable Upper respiratory tract infections
: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis and otitis media, and also
Lower respiratory tract infections
: bronchitis (acute and chronic), lobar pneumonia and bronchopneumonia.
Urinary tract infections
: cystitis, urethritis and pyelonephritis.
Skin and soft tissue infections
: abscess, cellulitis, furunculosis and impetigo.
The following microorganisms are susceptible, in vitro to Abac:
Gram-positive
: Staphylococci (both penicillin sensitive and resistant strains and penicillinase-producing species), Streptococci, Streptococci pyogenes (beta haemolytic), Streptococcus pneumonia.
Gram-negative
: Escherichia coli, Klebsiella spp, Proteus mirabilis, Haemophilus influenza, Shigella spp, Salmonella spp (including Salmonella typhi), Neisseria spp Many strains of E.coli and Staphylococcus aureus that produce the enzyme penicillinase and thus are ampicillin resistant, are susceptible to Abac which is unaffected by this enzyme.

💊 Dosage & Administration

For oral administration
-
Adults:
Urinary tract infections: 500mg four times daily or 1g twice daily. Infections which are severe or chronic may necessitate the administration of higher doses. Where complications arise including prostatitis and epididymitis continued intensive treatment is required.
Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily, dependent on the site and severity of the infection.
Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily, again dependent on the site and severity of the infection.
Children:
Total daily dose of 25 to 50mg/kg given in two or four equally divided doses.
Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly.
Maximum daily dosage: 4 gm
Elderly: The normal adult dose is appropriate. Patients with impaired renal or hepatic function should be monitored during treatment.
For injectable administration
-
Adult: The usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily. For prophylaxis a single preoperative dose of 1-2 gm intramuscularly or intravenously is given.
Children: The dose is 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection.

⚠️ Contraindications

Cephradine should not be used in patients with known or suspected hypersensitivity to cephalosporins.

⚡ Side Effects & Adverse Reactions

Limited essentially to gastro-intestinal disturbances and on occasions to hypersensitivity phenomena. The latter are more likely to occur in individuals, who have previously demonstrated hypersensitivity and thos with a history of allergy, asthma, hay fever or urticaria. Skin reactions have occasionally been reported. Rare- Glossitis, heartburn, dizziness, tightness in the chest, nausea, vomiting, diarrhoea, abdominal pain, vaginitis, candida overgrowth. Skin and hypersensitivity reactions include urticaria, skin rashes, joint pains, oedema.
Blood and lymphatic system disorders- Unknown: blood disorders (including thrombocytopenia, leucopenia, agranulocytosis, aplastic anaemia and haemolytic anaemia)
Immune system disorders- Unknown: Fever, serum sickness like reactions, anaphylaxis
Psychiatric disorders- Unknown: Confusion, sleep disturbances
Nervous system disorders- Unknown: hyperactivity, hypertonia, dizziness, nervousness; Rarely: Headache
Hepatobiliary disorders- Frequency unknown: Liver, enzyme disturbances, transient hepatitis, cholestatic jaundice
Renal and urinary disorders- Unknown: Reversible interstitial nephritis
Investigations- Unknown: Elevation of blood urea nitrogen, serum creatinine, alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase.

🛡️ Warnings & Precautions

Prolonged use of an anti-infective may result in the development of superinfection due to the emergence of resistant organisms.
Abac should be administered with care to patients hypersensitive to penicillins because of the risk of cross-sensitivity between beta-lactam antibiotics.
Cephalosporin antibiotics may cause a positive result in Coombs’ testing. When Coombs testing is performed on neonates whose mothers received cephalosporins prior to labour, it should be noted that a positive result may be due to the drug.
Abac may cause a false positive urine glucose result when Benedict’s or Fehling’s solutions or tablets such as Clinitest are used in the testing. This does not occur with enzyme-based tests (e.g. Clinistix, Diastix).
Dosage adjustment is necessary in renal impairment.
Abac contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

🔬 Pharmacology & Mechanism

Cephradine is a semisynthetic broad spectrum bactericidal antibiotic, it is active against infections caused by both gram-positive and gram-negative microorganisms. Both penicillinase producing and nonproducing staphylococci are sensitive to Cephradine. The main site of action of Cephradine is the cell wall of bacteria. Cell wall of sensitive organism contains peptidoglycan. Cephradine inhibits cross-linking process and as a result cell wall with many pores are formed, thus lysis of bacteria occur due to external osmotic pressure.

Cephradine

💊 Brand Formulations & Prices

Amfrad

Bactokil

Edin

Efrad

Intracef

Procef

Sefnin

Cephid

Orgacef

Polycef

Sefro

Brace

Sinaceph

Ultrasef

Ceframed

Elocef

Lindex

Sefin

Urodin

Velox

Sefacin

Betasef

Cefracef

Dicef

Extracef

Multicef

SK-cef

Supracef

Avlosef

Lebac

Sefril

Keprad

G-Cefradine

Rocef

Sefrad

Ceproval

Mega Cef

Acefra

Cefadin

Ceframax

Ceframed

Novadin

Sporin

Urodin

Revoc

Belocef

Brace

P-Cef

Adecef

Alfradin

Bactacef

Bactokil

Cefranov

Cephid

Cephradex

Edin

Efrad

Glovocef

Intracef

Lidocef

Recepra

Sefacin

Sefnin

Sefrate

Seftec

Sephar

Vecef

Wincef

Amfrad

Libradin

Mycef

Orgacef

Polycef

Mefrad

Roxicef

Sicef

Ultrasef

Sefin