OshudCenobamate
Adjunct anti-epileptic drugs
Brands & Prices (5)
📋 Indications & Uses Dosage & Administration⚠️ Contraindications⚡ Side Effects & Adverse Reactions🛡️ Warnings & Precautions🔬 Pharmacology & Mechanism
Brand Formulations & Prices
5 brands sorted by unit price
Cenomate
Afalino
Afalino
Cenomate
Afalino
📖 Official Clinical Monograph
DGDA Approved Prescribing GuidelinesAfalino is indicated for the treatment of partial-onset seizures in adult patients.
Dosage & AdministrationCenobamate can be taken with or without food, or as recommended by a physician. Recommended dosage for partial-onset seizures in adult-
Initial Dosage
: For Week 1 and 2 dose is 12.5 mg once daily
Titration Regimen
:
For Week 3 and 4 dose is 25 mg once daily
For Week 5 and 6 dose is 50 mg once daily
For Week 7 and 8 dose is 100 mg once daily
For Week 9 and 10 dose is 150 mg once daily
Maintenance Dosage
: For Week 11 and thereafter dose is 200 mg once daily
Maximum Dosage
: If needed based on clinical response and tolerability, the dose may be increased above 200 mg by increments of 50 mg once daily every two weeks to 400 mg once daily.
Cenobamate is contraindicated in patients with a known-
Hypersensitivity to either Cenobamate or to any excipients in Cenobamate.
Familial Short QT syndrome
Common
: Somnolence, fatigue, dizziness or feeling sleepy, nausea, constipation, double vision, decreased appetite, diarrhea, or weakness may occur.
Rare
: A very serious allergic reaction to Afalino is rare.
Potential adverse effects such as Multiorgan hypersensitivity reaction, QT shortening, and Suicidal thoughts. Somnolence and fatigue should be periodically re-evaluated. During Afalino therapeutic regimen, patients are advised not to drive or operate machinery. Afalino should be gradually withdrawn to minimize the potential or increased seizure frequency.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) / Multi-Organ Hypersensitivity: Discontinue if no alternate etiology.
QT Shortening: Use caution when administering Afalino with other drugs that shorten the QT interval
Suicidal Behavior and Ideation: Monitor patients for suicidal behavior and ideation.
Neurological Adverse Reactions: Monitor for somnolence and fatigue and advise patients not to drive or operate machinery until they have gained sufficient experience on Afalino. Concomitant use with other CNS depressants or alcohol may have additive effects.
Withdrawal of Antiepileptic Drugs: Afalino should be gradually withdrawn to minimize the potential of increased seizure frequency
Cenobamate is a positive GABA-A modulator which inhibits voltage-gated sodium channels. Inhibition of voltage-gated sodium channels increases the threshold for generating action potentials and decreases the number of action potentials. Its dual, complementary mechanisms of action may contribute to superior anti-seizure activity.