Cefixime Trihydrate

390 Registered Brands From ৳23.00 / unit

Third generation cephalosporins

Brands & Prices (390) 📋 Indications & Uses

Dosage & Administration ⚠️ Contraindications ⚡ Side Effects & Adverse Reactions 🛡️ Warnings & Precautions 🔬 Pharmacology & Mechanism

Brand Formulations & Prices

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📖 Official Clinical Monograph

DGDA Approved Prescribing Guidelines

📋 Indications & Uses

3-C is an orally active cephalosporin antibiotic which has marked in-vitro bactericidal activity against a wide variety of Gram-positive and Gram-negative organism. It is indicated for the treatment of the following acute infections when caused by susceptible microorganisms.
Upper Respiratory Tract Infections (URTI)
: e.g. otitis media; and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics, or where treatment failure may carry significant risk. Lower Respiratory Tract Infections-e.g. bronchitis.
Urinary Tract Infections
: e.g. cystitis, cystourethritis, pyelonephritis. Clinical efficacy has been demonstrated in infections caused by commonly occurring pathogens including Streptococcus pneumonia, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative) and Enterobacter species. 3-C is highly stable in the presence of beta-lactamase enzymes.

Dosage & Administration

Absorption of Cefixime is not significantly modified by the presence of food. The usual course of treatment is 7 days. This may be continued for up to 14 days if required.
Adults and children over 10 years
: The recommended adult dosage is 200-400 mg daily according to the severity of the infection, given either as a single dose or in two divided doses.
Elderly
: Elderly patients may be given the same dose as recommended for adults. Renal function should be assessed and dosage should be adjusted in severe renal impairment.
Children
: The recommended dosage for children is 8 mg/kg/day administered as a single dose or in two divided doses. As a general guide for prescribing in children the following daily doses in terms of volume of suspension are suggested:
6 months up to 1 year: 3.75 ml daily
Children 1-4 years: 5 ml daily
Children 5-10 years: 10 ml daily
In typhoid
: the recommended children dose is 5 mg/kg body weight twice daily for 10-14 days.
Children weighing more than 50 kg or older than 10 years
: Should be treated with the recommended adult dose 200-400 mg daily depending on the severity of infection.
Children aged less than 6 months
: The safety and efficacy of Cefixime has not been established in children aged less than 6 months.
Dosage in Renal Impairment
: Cefixime may be administered in the presence of impaired renal function. Normal dose and schedule may be given in patients with creatinine clearances of 20 ml/min or greater. In patients whose creatinine clearance is less than 20 ml/min, it is recommended that a dose of 200 mg once daily should not be exceeded. The dose and regimen for patients who are maintained on chronic ambulatory peritoneal dialysis or haemodialysis should follow the same recommendation as that for patients with creatinine clearances of less than 20 ml/min.

⚠️ Contraindications

Patients with known hypersensitivity to cephalosporin antibiotics.

⚡ Side Effects & Adverse Reactions

3-C is generally well tolerated. The majority of adverse reactions observed in clinical trials were mild and self limiting in nature. Gastrointestinal disturbances: The most frequent side-effects seen with 3-C are diarrhoea and stool changes; diarrhoea has been more commonly associated with higher doses. Other gastrointestinal side-effects seen less frequently are nausea, abdominal pain, dyspepsia, vomiting and flatulence. Pseudomembraneous colitis has been reported. Central nervous system: headache and dizziness. Hypersensitivity reactions: allergies in the form of rash, pruritis, urticaria, drug fever and arthralgia have been observed. These reactions usually subsided upon discontinuation of therapy. Hematological and clinical chemistry: thrombocytopenia, leukopenia and eosinophilia have been reported. These reactions were infrequent and reversible. Mild transient change in liver and renal function tests have been observed. Miscellaneous: other possible reactions include genital pruritis and vaginitis.

🛡️ Warnings & Precautions

3-C should be given with caution to patients who have shown hypersensitivity to other drugs. Cephalosporin should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and the cephalosporins. Patients have had severe reactions (including anaphylaxis) to both classes of drugs. If an allergic effect occurs with 3-C, the drug should be discontinued and the patient treated with appropriate agents if necessary. 3-C should be administered with caution in patients with markedly impaired renal function. Treatment with broad spectrum antibiotics alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of antibiotic-associated diarrhoea. Use in pregnancy and lactation: There are no adequate and well-controlled studies in pregnant women. 3-C should therefore not be used in pregnancy or in nursing mothers unless considered essential by the physician.

🔬 Pharmacology & Mechanism

Cefixime is a third generation semisynthetic cephalosporin antibiotic for oral administration. It is bactericidal against a broad spectrum of gram positive and gram negative bacteria at easily achievable plasma concentrations. It kills bacteria by interfering in the synthesis of bacterial cell wall. It is highly stable in the presence of Beta-lactamase enzyme. As a result, many organisms resistant to penicillins and some cephalsporins due to the presence of beta-lactamases, may be susceptible to Cefixime. Absorption of it is about 40% to 50% whether administered with or without food.

Cefixime Trihydrate

Brand Formulations & Prices

G-Cefixime

Ceferon

Hyxim

Masil

Suffix

Zenicef

Cefocef

Tricef

Xylocef

3RD Cef

Cef-Plus

3-Geocef

Adexim

Amucef

Bioxim

Cefesta

Cefivic

Cemaxi

Cemix-3

Erafix

Gen-3

Globexim

Keor

Novacef

Rescure

Sonexim

Trixim

Unifix

Xifim

Kefim

Fixim

Afixime

Microcef

Suprax

Cosmoxim

Cefiget

Cefim-3

G-Cefixime

Saver

3-C

Aegis

Afix

Alfixim

Bactazim

Bestcef

C-3

Cebex

Cefimax

Cefix

Cefixim

Cefmix

Ceftem

D-Fix

Duracef

Elexime

Emixef

Emixef

Excef

Fixotim

Neofexim

Neofix

Odacef

Ofex

Orcef

Orcef

Polyxim

Prex-3

Prexim

Profix

Supraxim

Tdcef

Tdcef

Tinfix

Trifix

Tyfax

Verixim

Ceftid

Infa-3